Author's response to reviews Title: Cost-effectiveness analysis of quadrivalent seasonal influenza vaccines in England Authors: Dominic Thorrington ([email protected])
نویسندگان
چکیده
The authors examine the incremental cost-effectiveness of using quadrivalent influenza vaccines rather than trivalent vaccines in various age and risk groups in England, finding that use of quadrivalent vaccines in pediatric groups was most likely to be cost-effective (i.e., with the greatest incremental cost per quadrivalent dose), with extending quadrivalent vaccination to high risk adults or to the elderly having less of an incremental cost per dose margin to maintain costeffectiveness at £20,000-30,000/QALY thresholds. Their modeling exercise and results are clearly reported overall, but would benefit from some clarification on trivalent vaccine effectiveness values used in the model, the rationale for no consideration of vaccination at ages <2 years, and justification for using a 90% criterion for cost-effectiveness acceptability, along with some more minor issues.
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Two antigenically distinct lineages of influenza B viruses have circulated globally since 1985. However, licensed trivalent seasonal influenza vaccines contain antigens from only a single influenza B virus and thus provide limited immunity against circulating influenza B strains of the lineage not present in the vaccine. In recent years, predictions about which B lineage will predominate in an ...
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